TAK-243 preferentially bound to UBA1 more than the related E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 reduced levels of ubiquitylated proteins, increased markers of proteotoxic strain and DNA hurt worry. In vivo, TAK-243 decreased leukemic burden and specific leukemic stem cells devoid https://epz00477733109.myparisblog.com/29407502/detailed-notes-on-sarolaner