In truth, TERT phosphorylation is shown being necessary for telomerase activation. b Outcome of BETi on telomere regulation. BETi compete with acetylated histones with the binding with the BRD4 bromodomains releasing BRD4 from shorter telomere, destabilizing telomere safety complex Group and decreasing Telomerase activity. The progressive shortening of telomere potential https://-jq-1inepigenetics24578.dailyhitblog.com/37337504/jq-1-as-a-bet-inhibitor-secrets