You will find there's release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to lower afferent suffering transmission and make analgesia. For that reason, drugs like clonidine that focus on alpha-two receptors can impact the transmission of ache. : linked to, https://www.proleviate.com/post/the-new-pain-killer-conolidine