Poor/Comprehensive Metabolizers, CYP2D6 The development in the Lively metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Somewhere around 7% from the population has lowered exercise of the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme program. These men and women are “very poor metabolizers” of debrisoquine, dextromethorphan and tricyclic antidepressants, https://elizabethb890toi4.activablog.com/profile